Cymbalta is used to treat major depression, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain in adults, with some indications extending to children. It is a brand name for duloxetine. Cymbalta is used to treat generalized anxiety disorder and fibromyalgia in some children. The pediatric dose for these conditions is typically lower than the adult dose. Cymbalta is FDA-approved not only for major depression but also for fibromyalgia, diabetic nerve pain, and generalized anxiety disorder. That makes it especially useful when depression overlaps with a chronic pain condition. Cymbalta (duloxetine) is a prescription drug for anxiety, pain from diabetic neuropathy, and other conditions. Learn about side effects, dosage, uses, and more. Duloxetine is used to treat depression and anxiety. It is also used for pain caused by nerve damage associated with diabetes (diabetic peripheral neuropathy). Duloxetine is also used to treat fibromyalgia (muscle pain and stiffness) and chronic (long-lasting) pain that is related to muscles and bones. Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be unbalanced in people with depression. Cymbalta is used to treat major depressive disorder in adults. Find patient medical information for Duloxetine (Cymbalta, Drizalma Sprinkle) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Cymbalta (duloxetine hydrochloride) is an antidepressant in the serotonin-norepinephrine reuptake inhibitor (SNRI) category. It is taken by mouth, as a pill or capsule, and can be prescribed for certain depression and anxiety disorders. Cymbalta is the brand name for duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI). It's FDA-approved for major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathy, fibromyalgia, and chronic musculoskeletal pain. Cymbalta is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD), generalized anxiety disorder and pain conditions.